294 RELATION OF SMALL DENSE LOW-DENSITY LIPOPROTEIN CHOLESTEROL TO CAROTID ATHEROSCLEROSIS IN ESSENTIAL HYPERTENSIVES WITH NORMAL RENAL FUNCTION

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Objectives: Recently, small dense low-density lipoprotein cholesterol (sdLDL-C) has been highlighted as the most atherogenic lipoprotein in cardiovascular disease. In this study, the relations of sdLDL-C and other lipid parameters to surrogate markers of atherosclerosis were investigated in essential hypertensives (EHT) with normal renal function. Design and Methods: In 137 untreated EHT with GFR≥60 mL/min, plasma levels of sdLDL-C (using assay kit supplied by Denka Seiken Co., Ltd., Niigata, Japan), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), adiponectin and norepinephrine, and blood sugar were measured. Intima-media thickness (IMT) and stiffness index β (β) of carotid artery (i.e., index for wall thickness and arterial stiffness of large artery, respectively) was also evaluated by B-mode ultrasonography and ultrasonic phase-locked echo-tracking system, respectively. Results: Although LDL, TG and HDL-C did not associate with IMT, sdLDL-C and ratio of sdLDL-C to LDL significantly correlated with IMT (r = 0.226, 0.181, p < 0.05 of each). Multiple regression analysis demonstrated that sdLDL-C was an independent determinant for IMT together with age, blood sugar and plasma levels of adiponectin and norepinephrine (r2 = 0.323, P < 0.05). In contrast, sdLDL-C and the other lipoproteins did not relate to β. In addition, either blood pressure or pulse rate did not associate with IMT and β. Conclusions: These results indicate that in EHT with normal renal function, sdLDL was the best marker for large arterial wall thickness among lipid parameters, and suggest that quantitative measurement of sdLDL could give the useful information for atherosclerosis compared with systemic hemodynamics.

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