Comparação da Eficácia de um Protocolo Acelerado de Estresse com Dobutamina Usando Injeção Precoce de Atropina na Cintilografia Miocárdica de Perfusão Comparison of the Efficacy of a New Accelerated Stress Protocol with Dobutamine Using Early Injection of Atropine in Myocardial Perfusion Scintigraphy

Résumé fourni par la source

Objective: To compare two stress protocols with Dob in patients undergoing myocardial perfusion scintigraphy (MPS). Methods: 168 patients undergoing Dob-MPS were consecutively studied. Two protocols were used randomly: progressive doses of Dob (steps of 10mg/kg/min at 3min intervals) up to 40mg/kg/min, aiming a minimum of 85% of the age corrected maximal predicted heart rate (HR), possibly adding atropine to maximal Dob dose in case HR was not achieved (conventional protocol) or progressive doses of Dob aiming at the same HR, but adding atropine at the end of the first stage (accelerated protocol). We compared age, gender, coronary risk factors, angina, history of myocardial infarction or revascularization, maximal HR, percentage of maximal predicted HR, rate-pressure product, ST changes and MPS scores. Results: Both groups presented similar demographic and clinical characteristics. We did not observe significant differences between the groups as maximal HR, percentage of achieved maximal HR, rate pressure product, ST changes, incidence of normal scans and perfusion scores. Conclusion: A new protocol with early atropine administration achieved the same perfusion scores in MPS as the conventional Dob protocol.