Long-Term Outcome of Radiotherapy for Mucoepidermoid Carcinoma of the Head and Neck Region

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Purpose: To analyze the long-term treatment outcome and various prognostic factors in patients with mucoepidermoid carcinoma (MEC) arising from the head and neck region treated by radiotherapy with or without surgery.Materials and Methods: Thirty-seven patients with previously untreated MEC in the head and neck region who received at least 50 Gy of radiotherapy with or without precedent surgery from June 1984 to May 2009 were enrolled in this study. The relationship between clinical and pathologic characteristics and survival rate was investigatedResults: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 85.5% and 83.2% respectively. Univariate analysis of OS demonstrated that the parameters which significantly affected survival were the gender (P=0.0005), age (P=0.0008), surgical margin (P=0.0031), treatment modality (P=0.0045), primary tumor site (P=0.0307), and histological grade (P=0.0328). The treatment modality (P=0.0014), surgical margin (P=0.0086), and gender (P=0.0175) were predictive factors of DFSConclusion: In univariate analysis, female gender, free surgical margins, and treatment by surgery plus radiotherapy were favorable prognostic factors in predicting both OS and DFS. Older age, non-parotid origin, and high grade tumor indicated worse OS.

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