Abstract 12338: N-Terminal Probrain Natriuretic Peptide is a Strong Predictor of Long-Term Mortality in Patients With Severe Sepsis and Septic Shock. Data From the Albumin Italian Outcome Sepsis Study

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Background: Myocardial depression is a common finding in severe sepsis, related to hemodynamic, metabolic and structural abnormalities. It is associated with increased morbidity and mortality. Although no pathogenic treatment is available, circulating biomarkers may be helpful for clinical management and early stratification of risk. Aims: To evaluate the clinical utility of circulating biomarkers of myocardial stress and injury in a large, representative cohort of patients with severe sepsis. Methods: Blood samples were collected 1, 2 and 7 days after enrolment in 995 patients with severe sepsis or septic shock enrolled in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial (NCT00707122). N-terminal proBNP (NT-proBNP) and high sensitivity cardiac troponin T (hs-cTnT) were measured in a central laboratory with an electrochemiluminescent assay (Roche Diagnostics). We evaluated the relations between biomarker concentrations, clinical characteristics, 90-day mortality, and the effect of randomized ...

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