ANTIOXIDANT AND ANTIHEMOLYTIC POTENTIALS OF PHYSOSPERMUM CORNOBIENSE (L.) DC.

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Summary The antioxidative and antihemolytic potentials of hydroalcoholic extract of Physospermum cornobiense was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, hydrogen peroxide, ferrous ion chelating, reducing power, hemoglobin induced linoleic acid and hydrogen peroxide induced hemolysis assays. The hydroalcoholic extract showed good activity in all antioxidant assays and contained a high level of total phenolic and flavonoid contents. IC50 values were 665.9 ± 33, 157.5 ± 6 and 156.4 ± 5.31 µg ml -1 in DPPH, hydrogen peroxide and nitric oxide radical inhibition, respectively. The extract also exhibited significant activity in nitric oxide scavenging, attributed to the high amount of phenolics. Moreover, Physospermum cornobiense extract showed strong reducing power and a notable capacity to suppress hemolysis.

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