Antilithiatic Activity of Ethanolic Extract of Hamelia patens (Leaves) on Ethylene Glycol Induced Lithiasis in Rats

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Indian traditional medicine is based on various systems including ayurveda, siddha and unani. The evaluation of these drugs is mostly based on phytochemical , pharmacological and allied approaches including various instrumental techniques like chromatography, microscopy and others. These traditional systems of Indian medicine have their uniqueness no doubt but there is a common thread running through these systems in their fundamental principle and practices with the emerging interest in the world to adopt and study the traditional and to exploit their potentials based on different health care system. The ethanolic extract of leaves of Hamelia patens. (EEHP) Jacq was evaluated for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated water (0.75%) in Adult male albino Wistar rats for 28 days. The ionic levels of urine was altered by ethylene glycol (EG), whi ch elevated the urinary concentration of crucial ions, Viz. calcium, phosphate, uric acid and oxalate there by contributing to renal stone formation. The EEHP, however significantly (P<0.05) reduced the elevated levels of these ions in urine. Also, it elev ated concentration of urinary magnesium, which is considered as one of the inhibitor of crystallization. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerate d glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol. This was reduced; however after treatment with EEHP. These observations enable to conclude that EEHP is effective against ethylene glycol induced Lithiasis. Abstract Indian traditional medicine is based on various systems including ayurveda, siddha and unani. The evaluation of these drugs is mostly based on phytochemical , pharmacological and allied approaches including various instrumental techniques like chromatography, microscopy and others. These traditional systems of Indian medicine have their uniqueness no doubt but there is a common thread running through these systems in their fundamental principle and practices with the emerging interest in the world to adopt and study the traditional and to exploit their potentials based on different health care system. The ethanolic extract of leaves of Hamelia patens. (EEHP) Jacq was evaluated for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated water (0.75%) in Adult male albino Wistar rats for 28 days. The ionic levels of urine was altered by ethylene glycol (EG), whi ch elevated the urinary concentration of crucial ions, Viz. calcium, phosphate, uric acid and oxalate there by contributing to renal stone formation. The EEHP, however significantly (P<0.05) reduced the elevated levels of these ions in urine. Also, it elev ated concentration of urinary magnesium, which is considered as one of the inhibitor of crystallization. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerate d glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol. This was reduced; however after treatment with EEHP. These observations enable to conclude that EEHP is effective against ethylene glycol induced Lithiasis. Abstract Indian traditional medicine is based on various systems including ayurveda, siddha and unani. The evaluation of these drugs is mostly based on phytochemical , pharmacological and allied approaches including various instrumental techniques like chromatography, microscopy and others. These traditional systems of Indian medicine have their uniqueness no doubt but there is a common thread running through these systems in their fundamental principle and practices with the emerging interest in the world to adopt and study the traditional and to exploit their potentials based on different health care system. The ethanolic extract of leaves of Hamelia patens. (EEHP) Jacq was evaluated for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated water (0.75%) in Adult male albino Wistar rats for 28 days. The ionic levels of urine was altered by ethylene glycol (EG), whi ch elevated the urinary concentration of crucial ions, Viz. calcium, phosphate, uric acid and oxalate there by contributing to renal stone formation. The EEHP, however significantly (P<0.05) reduced the elevated levels of these ions in urine. Also, it elev ated concentration of urinary magnesium, which is considered as one of the inhibitor of crystallization. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerate d glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol. This was reduced; however after treatment with EEHP. These observations enable to conclude that EEHP is effective against ethylene glycol induced Lithiasis.

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