Accès ouvert déclaré
2015
article
Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension
Thomas D. Giles, George L. Bakris, Suzanne Oparil, Michael A. Weber, Huiling Li, Madhuja Mallick, David B. Bharucha, Chun-Lin Chen, William Ferguson, John Sorin, Matthew C. Davis, J Oseph F. R Izzo, Nabile Andrawis, Alyn Anderson, Rogelio Bardinas-Rodriguez, Douglas A. Young, Andrew Schreiber, Cristian Breton, Duane G. Harris, Phillip LaStella, Ramón Castelló, Susan Hole, Luis Carlos Quintero, Carlos Eduardo Lucena Montenegro, Jeffrey B. Rosen, Farid Marquez, Fredric Adler, Sady Alpizar, James Andersen, Corey L. Anderson, Graciela Calatayud, Kevin Cannon, Deanna G. Cheung, Rafel Chiong, Lisa Cohen, Harry Collins, Michael Dao, Cara H. Dawson, Donna DeSantis, Shelly Dunmyer, Shérif M. El-Harazi, Cecil M. Farrington, David Ferrera, Gregory S. Funk, Gregory Gottschlich, Terence T. Hart, Marvin Kalafer, Dean J. Kereiakes, Gigi Lefebvre, Aristolis Laliotis, Peter Mattar, Diane McConnehey, Curtis J. Mello, Joel Neutel, Deborah A. Burke, J. D. Pritchard, George Raad, Bruce Rankin, John Chip Reed, Erich Lloyd Schramm, Howard Schwartz, Nathan Segall, James Shoemaker, Vakas Sial, Teresa Sligh, William B. Smith, Richard E. Stewart, Dan Streja, Danny Sugimoto, Alexander White, Hayes Williams, William Abraham, Azazuddin Ahmed, Richard Beasley, Daniel Gruener, Connie Hsu, Ryan R. Klein, Allen Soo, Charles P. Andrews, Clinton N. Corder, Donald Hurley, Elizabeth M Bretton, Richard Martinez, David P. Morin, Miguel Trevino, Samir Arora, Curtis Scott Horn, Charles Lovell, Thomas Nussdorfer, Robert E. Weiss, Harold Bays, Jackson Rhudy, Edwardo Almaguer, Joseph H. Woolley, Vicki Miller, Jaynier Moya-Hechevarria, Henry Punzi, Addison A. Taylor, Jonathan M. Wilson, Arnold Alper, Patricia Buchanan, Richard Dobrusin, Alan D. Forker, Razmig Krumian, Samuel F. Oberstein, Andrew Lewin, Mary Natividad, Armando Segui, Wayne L. Harper, Andrea Lawless, Lawrence S. Levinson, Shaukat Shah, Loray Blair‐Britt, Patrick Carmichael, Nathaniel Winer, David Grant, Kyle Rickner, Absalom Tilley, Linda Harper, Stephen Maddock, Joseph Boscia, Yekaterina Khronusova, L.D. Reed, Chandar Abboy
16Citations signalées, ce qui n’est pas une note de qualité
6Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
After demonstration of the antihypertensive efficacy of the combination of the beta-blocker nebivolol and the angiotensin receptor blocker valsartan in an 8-week, randomized, placebo-controlled trial (N = 4161), we now report the effects of this treatment on the renin-angiotensin-aldosterone system in a substudy (n = 805). Plasma renin activity increased with valsartan (54%-73%) and decreased with nebivolol (51%-65%) and the combination treatment (17%-39%). Plasma aldosterone decreased with individual treatments (valsartan, 11%-22%; nebivolol, 20%-26%), with the largest reduction (35%) observed with maximum combination dose (20 mg nebivolol/320 mg valsartan). Baseline ln(plasma renin activity) correlated with the 8-week reductions in 24-hour systolic and diastolic BP following treatments with the combination (all doses combined, P = .003 and P < .001) and nebivolol (both, P < .001), but not with valsartan. Baseline ln(aldosterone) correlated with 24-hour systolic and diastolic BP reductions following combination treatment only (P < .001 and P = .005). The implications of the renin-angiotensin-aldosterone system effects of this beta blocker-angiotensin receptor blocker combination should be explored further.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension
- Date Crossref
- 01/11/2015
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Blood Pressure and Hypertension StudiesHormonal Regulation and HypertensionSodium Intake and Health