Substrates of acute coronary syndromes: new insights into plaque rupture and erosion

Le résumé fourni par la source

Download the Issue @ a Glance podcast Subscribe to the EHJ Podcast Atherosclerotic plaques of various types are the substrate of acute coronary syndromes (ACS), which represents the most serious complication of the disease process.1 Atherosclerosis develops over decades; in fact it already tends to start in childhood. In a thought-provoking review article, ‘Lifetime risk: childhood obesity and cardiovascular risk’, David Celermajer from the Royal Prince Alfred Hospital in Camperdown, Australia and John Deanfield from University College London2 remind us of the potential threat of the current worldwide childhood obesity epidemic. As a result of the almost 50% increase in childhood obesity in the last 25 years, substantial concerns have been raised about the future burden of cardiovascular disease that could ensue. The authors review the evidence beyond current guideline knowledge3 linking early life obesity with adverse changes in cardiovascular structure and function already in childhood, discuss the focus on lifetime risk resulting from it, and highlight the potential effects of early lifestyle interventions.

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