MP12-14 VASCULAR TARGETED PHOTODYNAMIC THERAPY IN THE SWINE URETER: TRANSMURAL ABLATION DOES NOT PRODUCE OBSTRUCTION IN THE SUBACUTE SETTING

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You have accessJournal of UrologyImaging/Radiology III1 Apr 2014MP12-14 VASCULAR TARGETED PHOTODYNAMIC THERAPY IN THE SWINE URETER: TRANSMURAL ABLATION DOES NOT PRODUCE OBSTRUCTION IN THE SUBACUTE SETTING Ashley Winter, Simon Kimm, Haruyuki Takaki, Sebastien Monette, Avigdor Scherz, and Jonathan Coleman Ashley WinterAshley Winter More articles by this author , Simon KimmSimon Kimm More articles by this author , Haruyuki TakakiHaruyuki Takaki More articles by this author , Sebastien MonetteSebastien Monette More articles by this author , Avigdor ScherzAvigdor Scherz More articles by this author , and Jonathan ColemanJonathan Coleman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.449AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES An ideal technology for endoscopic management of upper tract urothelial tumors can penetrate the ureteral wall without resulting in perforation or obstruction. We created transmural ureteral ablations using percutaneously deployed vascular-targeted photodynamic therapy (VTP) in normal swine and monitored them for development of hydronephrosis and renal function deterioration. METHODS 5 female Yorkshire pigs were utilized. The photosensitizing agent, WST-11, was infused at a dose of 4mg/kg. Percutaneous access to the renal pelvis and ureter was established with ultrasound guidance. Light was delivered through a 2.0cm cylindrical diffusing fiber for 10 minutes at laser fluence of 200mW/cm. Animals underwent CT-urography at 24hrs, 1wk, and 2wks post-procedure. Blood-urea nitrogen (BUN) and creatinine levels were drawn at quarantine and prior to each CT. Animals were euthanized at 24hrs, 1 or 2 weeks. Kidneys, ureters, and bladder were harvested and submitted for review. RESULTS There was no change in BUN/Cr in any animal relative to baseline. No hydronephrosis or urine extravasation was noted weeks (Fig 1). Trichrome staining demonstrated preservation of ureteral collagen at 24hrs and restructuring of ablated areas at 2 weeks (Fig 2). CONCLUSIONS Vascular targeted photodynamic therapy produced transmural ureteral ablations with minimal morbidity in this pre-clinical trial. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e110-e111 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Ashley Winter More articles by this author Simon Kimm More articles by this author Haruyuki Takaki More articles by this author Sebastien Monette More articles by this author Avigdor Scherz More articles by this author Jonathan Coleman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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