Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes
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Le résumé fourni par la source
BACKGROUND: Increasing evidence suggests that diets high in polyunsaturated fatty acids (PUFA) confer health benefits by improving insulin sensitivity and lipid metabolism in liver, muscle and adipose tissue. METHODS: The present study investigates metabolic responses in two different lines of mice either selected for high body weight (DU6) leading to rapid obesity development, or selected for high treadmill performance (DUhTP) leading to a lean phenotype. At 29 days of age the mice were fed standard chow (7.2% fat, 25.7% protein), or a high-fat diet rich in n-3 PUFA (n-3 HFD, 27.7% fat, 19% protein) or a high-fat diet rich in n-6 PUFA (n-6 HFD, 27.7% fat, 18.6% protein) for 8 weeks. The aim of the study was to determine the effect of these PUFA-rich high-fat diets on the fatty acid profile and on the protein expression of key components of insulin signalling pathways. RESULTS: Plasma concentrations of leptin and insulin were higher in DU6 in comparison with DUhTP mice. The high-fat diets stimulated a strong increase in leptin levels and body fat only in DU6 mice. Muscle and liver fatty acid composition were clearly changed by dietary lipid composition. In both lines of mice n-3 HFD feeding significantly reduced the hepatic insulin receptor β protein concentration which may explain decreased insulin action in liver. In contrast, protein kinase C ζ expression increased strongly in abdominal fat of n-3 HFD fed DUhTP mice, indicating enhanced insulin sensitivity in adipose tissue. CONCLUSIONS: A diet high in n-3 PUFA may facilitate a shift from fuel deposition in liver to fuel storage as fat in adipose tissue in mice. Tissue specific changes in insulin sensitivity may describe, at least in part, the health improving properties of dietary n-3 PUFA. However, important genotype-diet interactions may explain why such diets have little effect in some population groups.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes
- Date Crossref
- 11/08/2011
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Veterinary Medicine Hannover Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Research Institute for Farm Animal Biology (FBN) pays non établi dans la noticeStructure de recherche
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Hannover Re (Germany) pays non établi dans la noticeEntreprise
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Massey University Institute of Food pays non établi dans la noticeUniversité ou école supérieure
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University of Auckland pays non établi dans la noticeUniversité ou école supérieure
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The University of Adelaide pays non établi dans la noticeUniversité ou école supérieure
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Zimmer Biomet (Germany) pays non établi dans la noticeEntreprise
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Leibniz Institute for Farm Animal Biology pays non établi dans la noticeStructure de recherche
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School of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Medical Sciences Discipline of Physiology pays non établi dans la noticeUniversité ou école supérieure
Department of Physiology — University of Veterinary Medicine Hannover, Research Institute for Farm Animal Biology (FBN) et Hannover Re (Germany), avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.