Avaliação macro e microscópica da cicatrização de lesões experimentalmente provocadas em pele de coelhos tratadas com secreção mucoglicoproteica do escargot Achatina fulica Evaluation of the Achatina fulica snail mucoglycoproteic secretion in surgical injury done in rabbits

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Abstract Escargots are animals capable to produce a glycoproteic secretion byglands located in all the surface of their bodies which among otherfunctions presents anti-bacterial power and participation in the ownimmunity. The antimicrobioan power of certain substances may aid ofrepair of wounds with several origins. Thus, the aim of the presentstudy was to evaluate macroscopic and histologically the reparative effectsof the mucus of Achatina fulica escargots on lesions made in the skin ofrabbits. Incisions were performed in the skin of 15 rabbits, separated inthree groups according to the treatment received. Immediately after thelesion, the respective treatments with pure mucus form and in ointmentform were supplied, while the other group received no treatment (controlgroup). The macroscopic characteristics of the lesion were registereddaily and a biopsy was performed 72 hours after the treatments. Thefragments were processed and stained with Masson’s trichrome. Themacroscopic evolution in the cicatrization process ocurred in a shorterperiod of time in rabbits from the ointment group, comparativity withthe other groups. Histologically, the epidermis of the treated rabbitsshowed a basal layer of cubic cells, while rabbits of the control grouppresented a basal layer of cylindrical cells with cutaneous debris.

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