Differences in Sonographic Conspicuity According to Papillary Thyroid Cancer Subtype: Results of the Ukrainian–American Cohort Study After the Chornobyl Accident
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Le résumé fourni par la source
OBJECTIVE: Over time, the histology of papillary thyroid cancers detected in a repeatedly screened population exposed to radiation at Chornobyl (Chernobyl) has shifted from a more aggressive subtype toward less aggressive subtypes. This change may reflect biologic behavior but could also be influenced by the detectability of different subtypes. The study objective was to identify whether there is any relationship between the conspicuity of sonographically detected papillary cancers and histologic subtype. MATERIALS AND METHODS: Sonographic images of 84 papillary cancers occurring in young people exposed to radiation at Chornobyl were each given a conspicuity score using a subjective 1-5 scale by four independent expert readers blinded to histologic subtype. The effects of tumor subtype, tumor encapsulation, reader, machine type, and nodule size on sonographic conspicuity were determined using analysis of variance and Spearman correlations. RESULTS: Cancer subtype was related to sonographic conspicuity (p < 0.01). The relatively aggressive solid subtype of papillary carcinoma was more conspicuous than the papillary, follicular, and mixed subtypes (p < 0.05). The other subtypes did not differ significantly from each other in conspicuity. Conspicuity was not significantly related to nodule size, degree of encapsulation, age and sex of the subject, or machine type. Although the mean conspicuity score for each reader differed significantly, reliability of conspicuity judgments across readers was fair. CONCLUSION: In subjects exposed to radiation from the Chornobyl accident, the solid subtype of papillary carcinoma appears to be more conspicuous on sonography than the other subtypes. Therefore, the change in subtype observed over time in this repeatedly screened population may be influenced by differences in nodule conspicuity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differences in Sonographic Conspicuity According to Papillary Thyroid Cancer Subtype: Results of the Ukrainian–American Cohort Study After the Chornobyl Accident
- Date Crossref
- 01/12/2008
- Éditeur
- American Roentgen Ray Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Thomas Jefferson University Hospital Department of Radiology pays non établi dans la noticeÉtablissement de santé
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V.P. Komisarenko Institute of Endocrinology and Metabolism pays non établi dans la noticeStructure de recherche
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Columbia University pays non établi dans la noticeUniversité ou école supérieure
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National Cancer Institute Division of Cancer Epidemiology and Genetics pays non établi dans la noticeOrganisme public
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Division of Cancer Epidemiology and Genetics pays non établi dans la noticeStructure de recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Diabetes and Digestive and Kidney Diseases pays non établi dans la noticeStructure de recherche
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College of Physicians and Surgeons Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Mailman School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Clinical Endocrinology Branch pays non établi dans la noticeÉtablissement de santé
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Deceased pays non établi dans la noticeInstitution
Department of Radiology — Thomas Jefferson University Hospital, V.P. Komisarenko Institute of Endocrinology and Metabolism et Columbia University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.