2013
article
Is Intrapartum Intravenous Zidovudine for Prevention of Mother-to-Child HIV-1 Transmission Still Useful in the Combination Antiretroviral Therapy Era?
Nelly Briand, Josiane Warszawski, Laurent Mandelbrot, Catherine Dollfus, E. Pannier, L. Cravello, Rose Nguyen, Norbert Winer, Roland Tubiana, Christine Rouzioux, Albert Faye, Stéphane Blanche, Françoise Meier, Dominique Duro, Marine Joras, E. Mortier, Catherine Crenn‐Hébert, Corinne Floch-Tudal, Fabienne Mazy, M. Bensalah, Agnès Villemant-Uludag, A. Lefort, Virginie Zarrouk, Pierre‐François Ceccaldi, Gisèle Philip, Gilles Hittinger, Martine Malet, B. Bachelard, Marie Medus, Joëlle Dendale-Nguyen, Jean-Pierre Brossier, Olivier Aubry, Jean-Luc Esnault, S Léautez, Philippe Van de Perre, Isabelle Suaud, Sandrine-Anne Martha, Mahfoud Rouha, Pascale Perfezou, G Blondin, Charles Bellot, Séverine Ansart, Philippe Le Moine, Karine Bages-Jaffuel, Jean-Charles Duthé, M. Garrè, S. Jaffuel, Corinne Daniel, Christian Calvez, C. Beuscart, Emmanuelle Boutaric, Jennifer Rohan, Sylvie Lemoal, L. Lassel, Ghislaine Cotten, Esther Beauville, C. Arvieux, Anabèle Dos Santos, Corinne Cudeville, Yves Poinsignon, Virginie Mouton-Rioux, Gaétane Mousset, Anne Grellier, Philippe Moreau, Philippe Tillaut, Odile Luycx-Vaillant, Philippe De Morel, Marie-Françoise Le Coz, Isabelle Belzic, M. Niault, Anne Vandenbergh, C. Janssen, Virginie Vitrat, J. Gaillat, Gaëlle Clavere, J.P. Bru, Blandine Peyret, Catherine Mullard, Marie Echard, Philippe Talon, Cécile Winter, Brigitte Heller-Roussin, Odile Launay, Ghislaine Firtion, Isabelle Goupil, Nora Boudjoudi, Agnès Bourgeois-Moine, Valérie Vivier, Mandovi Rajguru, Virginie Huri, Élie Azria, Sophie Matheron, Neila Elaoun, Philippe Faucher, Valérie Garrait, Christiane Kommé, Isabelle Hau, Laurent Richier, Claudine Touboul, V. Thoirain, Laurent Cotte, Olivier Tariel, J. Koffi, Jean-Marc Labaune, C. Brochier, Denis Roux, Christophe Elleau, Camille Runel, Henri Bataille, Marie-Thérèse Sow, Ketty Samar, Blandine Muanza, Clarisse Kingue-Ekollo, Bénédicte Carpentier, Isabelle Ronda, Jean-Marc Chamouilli, Natacha Entz‐Werlé, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, Yvon Lemercier, J Tricoire, Alain Berrébi, Michèle Antras, Evelyne Armand, Claudine Cayla, F. Bonnal, Catherine Chabanier, Anne Chacé, Sophie Couderc, Anne Boutemy, Marie-Christelle Dallot, A. Alissa, Corinne Routier, Ahmed S. Zakaria, Véronique Favret, Juliette Gerbe, E. Questiaux, Marialuisa Partisani, David Rey, Christine Cheneau, C Allisy, Dominique Brault, François Hervé, Marie-Gisèle Lebrette, Lise Selleret, Dieudonné Ekoukou, Pascal Bolot, Marie-Aude Khuong-Josses, Marie-Christine Allemon, N Ghibaudo, Pierre Frange, Florence Veber, Delphine Lemercier, Marie-Christine Mourey, Gilles Blasquez, Michèle Granier, Houda Touahri, Alain Devidas, I. Nisand, Michèle Weil, Christophe Vayssière, Jean‐Luc Berger, Martine Münzer, Olivier Graesslin, Anne-Florence Naime-Alix, Frédérique Quetin, Anne Laubies, Manuela Bonmarchand, Jennifer Sommer, Patricia Bourse, Anne Coursol, J. X. Laurent, Mariem Raho, V. Chambrin, Philippe Labrune, Laure Clech, Alexandra Benachi, Bertrand Le Lorier, Isolde Pauly-Ravelly, Claude Allouche, Ama Johnson, L. Benoist, C W deLannoy, Eric Lachassine, S Bolie, J. Gaudelus, Vincent Jeantils, Amelie Benabara, Leïla Karaoui, V Lefevre, A. Bongain, Eliane Galiba, Anne Deville, Fabrice Monpoux, J. Durant, Christian Aufrant, J Furioli, Jean-Louis Salomon, Françoise Granier, Antoine Doumet, Jean Gondry, J.L. Schmit, Brigitte Pautard, M. Gamerre, Isabelle Thuret, Laurence Neimann, Claire Hubert, B. Carbonne, G. Vaudre, Marie‐Dominique Tabone, Didier Pinquier, Gaëlle Pinto Cardoso, Brigitte Clavier, F. Borsa-Lebas, Agathe de Lauzanne, Constance Borie, Sandrine Leveillé, Erianna Bellaton, Dominique Garion, Martine Levine, C. Colmant, Cécile Goujard, Marc Tardieu, F. Fuchs, Ikram Jrad, Delphine Peretti, Katia Bourdic, Corinne Fourcade, Catherine Chirouze, Jean‐Marie Estavoyer, R Maillet, Véronique Reliquet, C. Brunet, Isabelle Reynaud, Claire Briandet, Jacques Brouard, Gaël Beucher, Pascale Goubin, Cécile Lanty, Eric Froguel, Béatrice Gourdel, A. Chalvon Demersay, Gilbert Algava, Véronique Hentgen, Fabienne Messaoudi, Pascale Nau, Jean‐Marc Besnier, J. Potin, Nadine Taché, Yves Bertrand, Kamila Kébaïli, Véronique Ronat, A. Frésard, Kareen Billiemaz, Ramona Abrudan, A Fournié, Jean-Marie Chennebault, Philippe Arsac, N Ciraru‐Vigneron, G Mouchnino, D Ayral, Nelly Guigue, Muriel Lalande, P Bénos, Christiane De Gennes, S. Chanzy, Valérie Isart, François Cazassus, Véronique Walter, François Bissuel, Yamina Hammou, Sophie d'Angelo, Faïza Ajana, Françoise Mazingue, R Mézin, Yves Hatchuel, André Cabie, Narcisse Elenga
128Citations signalées — pas une note de qualité
21Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Intrapartum intravenous zidovudine (ZDV) prophylaxis is a long-standing component of prevention of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in high-resource countries. In some recent guidelines, intravenous ZDV is no longer systematically recommended for mothers receiving combination antiretroviral therapy (cART) with low viral load. We evaluated the impact of intravenous ZDV according to viral load and obstetrical conditions. METHODS: All HIV-1-infected women delivering between 1 January 1997 and 31 December 2010 in the French Perinatal Cohort (ANRS-EPF) were analyzed if they received ART during pregnancy and did not breastfeed. We identified maternal and obstetrical characteristics related to lack of intravenous ZDV and compared its association with MTCT rate and other infant parameters, according to various risk factors. RESULTS: Intravenous ZDV was used in 95.2% of the 11 538 deliveries. Older age, multiparity, and preterm and vaginal delivery were associated with lack of intravenous ZDV (n = 554). In women who delivered with viral load ≥1000 copies/mL, the overall MTCT rate was higher without than with intravenous ZDV (7.5% vs 2.9%; P = .01); however, there was no such difference when the neonate received postnatal intensification therapy. Among them, 77% of women who had viral load <400 copies/mL, there was no difference in MTCT rate (0% without intravenous ZDV vs 0.6% with intravenous ZDV; P = .17). Intravenous ZDV was not associated with increased short-term hematological toxicity or lactate level. CONCLUSIONS: Intravenous ZDV remains an effective tool to reduce transmission in cases of virological failure, even in cART-treated women. However, for the vast majority of women with low viral loads at delivery, in the absence of obstetrical risk factors, systematic intravenous ZDV appears to be unnecessary.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Is Intrapartum Intravenous Zidovudine for Prevention of Mother-to-Child HIV-1 Transmission Still Useful in the Combination Antiretroviral Therapy Era?
- Date Crossref
- 31/05/2013
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV/AIDS Research and InterventionsHIV/AIDS drug development and treatmentHIV Research and Treatment