Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions
Rattachement africain : fr, ro. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIM: To appraise the tolerance and efficacy of an induction of tolerance protocol to infliximab permitting the re-administration of the drug to patients with Crohn's disease having had infusion reactions requiring suspension of treatment. METHODS: Fourteen patients were included in the induction of tolerance protocol. Each infusion of infliximab (5 mg/kg) was divided into 11 escalating 15 min increments over a 3-h time period. The induction of tolerance procedure was repeated for subsequent infusions. RESULTS: Ten patients (71.4%) received all the three infusions for the induction treatment. Nine (64.3%) had a significant response and six (48.8%) still benefited from infliximab infusions. Seven patients (50%) achieved a complete remission, after a mean of 2.5 (two to three) infusions. Four patients (28.6%) had no response and the protocol was stopped. Three patients (21.4%) experienced mild immediate hypersensitivity reactions, which were controlled, two patients (14.2%) experienced severe immediate hypersensitivity reactions, leading to interruption of the treatment and one patient developed a delayed hypersensitivity reaction. CONCLUSION: Our induction of tolerance protocol allows some patients who have experienced severe or repetitive infusion reactions to infliximab to be safely retreated with the drug in a hospitalized setting, with a clinical response achieved in a majority of these patients.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions
- Date Crossref
- 16/08/2006
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Centre Hospitalier Universitaire de Lille pays non établi dans la noticeÉtablissement de santé
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Lille’s Cardiology Hospital pays non établi dans la noticeÉtablissement de santé
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Institutul Clinic Fundeni pays non établi dans la noticeÉtablissement de santé
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Department of Hepato-Gastroenterology pays non établi dans la noticeInstitution
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Department of Hepatogastroenterology pays non établi dans la noticeInstitution
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Clinic of the Respiratory Diseases pays non établi dans la noticeÉtablissement de santé
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Fundeni Clinical Institute Center of Gastroenterology and Hepatology pays non établi dans la noticeStructure de recherche
Centre Hospitalier Universitaire de Lille, Lille’s Cardiology Hospital et Institutul Clinic Fundeni, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.