Incidence and causes of heparin-induced skin lesions
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Le résumé fourni par la source
BACKGROUND: Little is known about the incidence and causes of heparin-induced skin lesions. The 2 most commonly reported causes of heparin-induced skin lesions are immune-mediated heparin-induced thrombocytopenia and delayed-type hypersensitivity reactions. METHODS: We prospectively examined consecutive patients who received subcutaneous heparin (most often enoxaparin or nadroparin) for the presence of heparin-induced skin lesions. If such lesions were identified, we performed a skin biopsy, platelet count measurements, and antiplatelet-factor 4 antibody and allergy testing. RESULTS: We enrolled 320 patients. In total, 24 patients (7.5%, 95% confidence interval [CI] 4.7%-10.6%) had heparin-induced skin lesions. Delayed-type hypersensitivity reactions were identified as the cause in all 24 patients. One patient with histopathologic evidence of delayed-type hypersensitivity tested positive for antiplatelet-factor 4 antibodies. We identified the following risk factors for heparin-induced skin lesions: a body mass index greater than 25 (odds ratio [OR] 4.6, 95% CI 1.7-15.3), duration of heparin therapy longer than 9 days (OR 5.9, 95% CI 1.9-26.3) and female sex (OR 3.0, 95% CI 1.1-8.8). INTERPRETATION: Heparin-induced skin lesions are relatively common, have identifiable risk factors and are commonly caused by a delayed-type hypersensitivity reaction (type IV allergic response).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Incidence and causes of heparin-induced skin lesions
- Date Crossref
- 28/09/2009
- Éditeur
- CMA Joule Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Goethe University Frankfurt pays non établi dans la noticeUniversité ou école supérieure
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University of Lübeck Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Hospital of the Johann Wolfgang Goethe University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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From the Departments of Internal Medicine pays non établi dans la noticeInstitution
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DRK-Blooddonorservice (Kroll) pays non établi dans la noticeInstitution
Goethe University Frankfurt, Department of Dermatology — University of Lübeck et Department of Internal Medicine — Hospital of the Johann Wolfgang Goethe University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.