Distribution of Dendritic Cells and Regulatory T-Cells in Cutaneous Lymphomas
Rattachement africain : kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background : Dendritic cells (DCs) play an important role in immune reactions.This study was designed to identify the distribution patterns of DCs and regulatory T-cells (Tregs) in cutaneous lymphomas.Methods : Immunohistochemistry was used to determine langerin expression on Langerhans cells, CD11b on inflammatory DCs, CD209 and CD11c on dermal DCs, CD303 on plasmacytic DCs, and Foxp3 on Tregs in 81 cases of cutaneous lymphomas.Results : Various DCs and Tregs were identified in most cutaneous lymphomas.Plasmacytic DCs, inflammatory DCs and Tregs were identified mainly in tumor areas, whereas dermal DCs were distributed both in the tumor and stromal areas.Among DCs, dermal DCs were most prominently identified in the cutaneous lymphomas not only in the tumor area but also in the stroma.The intense stromal infiltration of dermal DCs was consistent finding in T-cell lymphomas.Diffuse large B-cell lymphoma (DLBCL), not otherwise specified also showed intense stromal infiltration of dermal DCs, but stromal infiltration in DLBCL, leg type was relatively scant.Conclusions : The results suggest that all types of DCs and Tregs are involved in cutaneous lymphoma tumor immunity.Among them dermal DCs may play a dominant role.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Distribution of Dendritic Cells and Regulatory T-Cells in Cutaneous Lymphomas
- Date Crossref
- 01/01/2010
- Éditeur
- The Korean Society of Pathologists and The Korean Society for Cytopathology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Catholic University of Korea St. Vincent's Hospital pays non établi dans la noticeÉtablissement de santé
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The Catholic University of Korea Seoul St. Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Catholic University of Korea Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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The Catholic University of Korea Yeouido St. Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Hospital Pathology pays non établi dans la noticeÉtablissement de santé
The Catholic University of Korea St. Vincent's Hospital, The Catholic University of Korea Seoul St. Mary's Hospital et Department of Internal Medicine — Catholic University of Korea, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.