No differences between men and women in adverse drug reactions related to psychotropic drugs: a survey from F rance, I taly and S pain
Rattachement africain : it, fr, es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
A large number of studies have suggested that being a woman represents a potential risk factor for the development of adverse drug reactions (ADRs). The aim of this study is to further explore the differences between men and women with regard to reported ADRs, particularly those associated with psychotropic drugs. We used spontaneous reports of suspected ADRs collected by Midi-Pyrénées (France), Veneto (Italy) and Castilla y León (Spain) Regional Pharmacovigilance Centres (January 2007-December 2009). All the reports including a psychotropic medication were selected in a first step; age distribution, seriousness and type of ADRs were compared between men and women. Reports of nonpsychotropic drugs were similarly identified and treated. The absolute number of reports and the proportion, considering population, were higher in women than in men. This was observed for all reports, but was particularly higher for psychotropic drugs (592 vs. 375; P < 0.001) than for nonpsychotropics drugs (5193 vs. 4035; P < 0.001). Antidepressants were the most reported (women, 303; men, 141; P < 0.001); the reporting rates (number of reports divided by exposed patients in the same period, estimated through sales data) for these drugs, however, were not significantly different between women (0.87 cases per 10 000 treated persons per year) and men (0.81 cases per 10 000 treated persons per year). Although there was a higher number of reports of ADRs in women, ADR reporting rates might be similar as highlighted by the case of antidepressants. Antidepressant ADRs in fact were similarly reported in men and in women. Gender differences are sometimes subtle and difficult to explore. International networks, as the one established for this study, do contribute to better analyse problems associated with medications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- No differences between men and women in adverse drug reactions related to psychotropic drugs: a survey from <scp>F</scp>rance, <scp>I</scp>taly and <scp>S</scp>pain
- Date Crossref
- 26/04/2013
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Verona pays non établi dans la noticeUniversité ou école supérieure
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Université Toulouse III - Paul Sabatier pays non établi dans la noticeUniversité ou école supérieure
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Inserm pays non établi dans la noticeOrganisme public
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Centre Hospitalier Universitaire de Toulouse pays non établi dans la noticeÉtablissement de santé
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Universidad de Valladolid pays non établi dans la noticeUniversité ou école supérieure
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Dipartimento di Sanità Pubblica e Medicina di Comunità Sezione di Farmacologia Università di Verona Verona Italy pays non établi dans la noticeInstitution
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Centre Midi‐Pyrénées de Pharmacovigilance et d'Information sur le Médicament Service de Pharmacologie Clinique Centre Hospitalier Universitaire Toulouse France pays non établi dans la noticeÉtablissement de santé
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Centro de Estudios sobre la Seguridad de los Medicamentos pays non établi dans la noticeInstitution
University of Verona, Université Toulouse III - Paul Sabatier et Inserm, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.