Opinion about reproductive decision making among individuals undergoing BRCA1/2 genetic testing in a multicentre Spanish cohort
Rattachement africain : es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Mutations in breast cancer BRCA1/2 genes increase breast and ovarian cancer risk and are transmitted with an autosomal dominant pattern. Opinion about reproductive decisions among individuals undergoing BRCA1/2 testing in our institutions is unknown. MATERIALS AND METHODS: Individuals (n = 77) undergoing BRCA1/2 testing were included in a prospective multicentre study to assess the clinical impact of genetic testing. Demographic and clinical information, psychological status and opinion about reproductive decisions were collected in two questionnaires administered prior to testing. Opinion regarding the use of assisted reproduction techniques for hereditary cancer susceptibility among health care professionals was also collected. RESULTS: Twenty-eight individuals (36%) reported that they would decide to have children, regardless of their result. In case of a mutation, 9 (12%) believed that they would decide not to have children, 42 (55%) would consider prenatal diagnosis (PND), 37 (48%) would consider preimplantation genetic diagnosis (PGD) and 23 (30%) would consider adoption. Fifty-seven (74%) and 47 (61%) reported that they considered it ethical to offer PND or PGD, respectively, to BRCA+ patients. Individuals older than 40 years were more likely to consider PND or PGD than younger subjects (P = 0.02 and 0.05, respectively). Individuals with cancer compared with those without a diagnosis of malignancy were more likely to consider PGD (61 versus 30%, P = 0.02) and to consider that it was ethical to offer it (74 versus 44%, P = 0.02). Most health care professionals were in favour of PND and PGD for individuals with hereditary cancer susceptibility (58 and 61%, respectively). CONCLUSIONS: BRCA1/2 genetic results could influence an individual's decisions regarding reproduction. Health care professionals who serve individuals undergoing BRCA testing should incorporate patient education regarding the potential impact of such testing on family planning.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Opinion about reproductive decision making among individuals undergoing BRCA1/2 genetic testing in a multicentre Spanish cohort
- Date Crossref
- 26/12/2008
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universitat Autònoma de Barcelona pays non établi dans la noticeUniversité ou école supérieure
-
Catalan Institute for Water Research pays non établi dans la noticeStructure de recherche
-
Institut Català d'Oncologia pays non établi dans la noticeOrganisme public
-
Hospital Universitari Sant Joan de Reus pays non établi dans la noticeÉtablissement de santé
-
Hospital de Sant Pau pays non établi dans la noticeÉtablissement de santé
-
Hospital Universitari Vall d'Hebron Medical Oncology Department pays non établi dans la noticeÉtablissement de santé
-
Catalan Institute of Oncology Cancer Genetic Counselling Program pays non établi dans la noticeStructure de recherche
-
Hospital Sant Joan de Reus Medical Oncology Department pays non établi dans la noticeÉtablissement de santé
-
Hospital de la Santa Creu i Sant Pau Medical Oncology Department pays non établi dans la noticeÉtablissement de santé
Universitat Autònoma de Barcelona, Catalan Institute for Water Research et Institut Català d'Oncologia, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.