p53 Proteinüberexpression in Ovarialkarzinomen: Korrelation mit histopathologischen Daten und klinischem Verlauf

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OBJECTIVES: The accumulation of p53 protein was analysed immunohistochemically in ovarian cancer and correlated with clinical data to further clarify the role of p53 mutations for prognosis in these patients. METHODS: Tumor tissues from 126 epithelial ovarian carcinomas were analysed immunohistochemically on paraffin embedded tissue and in 21 cases on frozen tissue with monoclonal antibodies PAb 1801, PAb 421 and PAb 240. RESULTS: Nuclear p53 staining was found in 31 ovarian carcinomas (25%) and correlated with advanced stage of the disease (p = 0,038) and poor differentiation (P = 0,032) of the tumor. Disease-free and overall-survival time were slightly, but not significantly shortened for patients with p53 positive tumors. CONCLUSION: Immunohistochemically detectable p53 protein expression in ovarian carcinoma is associated with poor differentiation, advanced stage of the disease and a tendency for shortened disease-free and overall survival.

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