Frederick Valentine Flynn

Résumé fourni par la source

Introduction: TB remains a significant public health problem through-out the developing world. Pulmonary TB is known to be a risk factor for Obstructive Airways Diseases (OAD). Aims and objectives: To determine the association and prevalence of OAD in patients with past history of Pulmonary Tuberculosis in absence of risk factors of OAD. Methodology: All patients with past H/O diagnosed and treated Pulmonary TB with minimal tobacco smoking or biomass fuel exposure who met the inclusion criteria were recruited. They were divided in 4 groups on the basis of duration after completing TB treatment – 6-12 months,1-2 years, 2-5 years, >5 years. Patients were subjected to detailed history taking, Chest radiograph and Spirometry. Results: 65 patients met the inclusion criteria over a period of 6 months.50% patients were above 50 years and 54% were men.83% patients had microbiologically proven TB. The prevalence of OAD was 44.62%. About 40% were been followed up on a routine basis whereas 50% presented with acute respiratory symptoms. Most of the patients (43%) had been treated for TB more than 5 years ago. Only 24% of patients had a history of smoking (<5 pack-years). The mean FEV1 in patients with OAD was 1.27. Based on Spirometric criteria (GOLD) no patients had mild COPD, 62% moderate disease, 28% had severe and 10% very severe disease. Conclusions: This pilot study reveals a high prevalence of OAD in patients previously treated for Pulmonary TB. Most of the affected subjects have moderate to severe disease who would benefit from bronchodilator±anti-inflammatory treatment. Hence, we hypothesize that Post TB treatment; patients should be followed up long term for the development of OAD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.