Which patients with hepatitis C develop liver complications?
Rattachement africain : au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
To identify variables that are independent predictors of adverse outcomes in chronic hepatitis C, we analyzed a cohort of 455 patients followed for a median of 4.7 years. Associations were sought between demographic and behavioral factors, hepatitis C virus (HCV) genotype, liver histology and liver tests at entry, and development of liver complications, hepatocellular carcinoma (HCC), hepatic transplantation and liver-related death. Independent predictors were identified by multivariate analysis. The following were associated with a significantly higher rate of liver complications: age; birth in Asia, Europe, Mediterranean region, or Egypt; transmission by blood transfusion or sporadic cases; HCV genotypes 1b and 4 (compared with 1/1a); fibrosis stage 3 or 4 (cirrhosis); serum albumin; bilirubin; prothrombin time; and alpha-fetoprotein. However, the only independent predictors of liver-related complications were sporadic transmission (P <.001), advanced fibrosis (P =.004), and low albumin (P <.001). The corresponding independent risk factors for HCC were male gender (P =. 07), sporadic transmission (P <.001), and albumin (P <.001); bilirubin (P =.02) was an additional predictor of transplantation or liver-related death. It is concluded that only patients with advanced hepatic fibrosis or cirrhosis, are at risk of developing hepatic complications of chronic hepatitis C during 5-year follow-up. Among such patients, abnormalities in serum albumin, bilirubin, or prothrombin time indicate a high probability of complications. Patients without definite risk factors for HCV (sporadic cases) are at higher risk of complications, possibly because of interaction between older age, duration of infection, country of birth, and HCV genotypes 1b and 4.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Which patients with hepatitis C develop liver complications?
- Date Crossref
- 01/02/2000
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
The University of Sydney pays non établi dans la noticeUniversité ou école supérieure
-
Children's Hospital at Westmead pays non établi dans la noticeÉtablissement de santé
-
Westmead Hospital Storr Liver Unit pays non établi dans la noticeÉtablissement de santé
-
Westmead Institute pays non établi dans la noticeStructure de recherche
-
Australian Centre for HIV and Hepatitis Virology Research pays non établi dans la noticeStructure de recherche
-
Division of Medicine pays non établi dans la noticeInstitution
-
Department of Anatomical Pathology pays non établi dans la noticeInstitution
-
Hepatitis Laboratory pays non établi dans la noticeStructure de recherche
The University of Sydney, Children's Hospital at Westmead et Storr Liver Unit — Westmead Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.