Neuroleptic malignant syndrome without fever: a report of three cases

Résumé fourni par la source

on both sides involving the vestibulospinal tracts bilaterally (figure C).Patients 2 and 3 also had high intensity areas in the same areas.Apart from lesions in this area, all showed high signal intensity areas in the cerebral white matter.This preliminary study shows that latencies of a vestibulospinal reflex can be prolonged in multiple sclerosis.As in these three patients the VEMPs were remarkably delayed rather than simply abolished as occurs in patients with peripheral vestibular lesions, 2-4 the VEMP delay could be attributed to demyelination either of primary aVerent axons at the root entry zone or secondary vestibulospinal tract axons rather than to lesions involving vestibular nucleus neurons.The MRI findings in these patients were not inconsistent with this proposition.Measurement of VEMPs could be a useful clinical test to evaluate function of the vestibulospinal pathway and for detecting subclinical vestibulospinal lesions in suspected multiple sclerosis.

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