Exploring the Effects of C-Reactive Protein (CRP) and Interleukin-1 β Single Nucleotide Polymorphisms on CRP Concentration in Patients With Established Coronary Artery Disease

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PURPOSE: This study was designed to illustrate the effects of C-reactive protein (CRP) and interleukin polymorphisms on serum CRP levels. METHODS: A total of 390 patients with coronary heart disease (CHD) were recruited and high-sensitivity CRP levels were measured. Six polymorphic alleles on the genes of CRP, IL-1, and the IL-1 receptor antagonist were identified. A classification tree was applied to determine their effects and interactions on serum CRP levels. RESULTS: In the hypertensive CHD patients, the presence of CRP + 1059 GC heterozygotes was associated with a lower risk for elevated CRP levels (OR = 0.318, P = 0.001). The coexistence of CRP + 1059 GC and IL-1beta-511 (CT or TT) might result in reduction in the CRP levels compared to IL-1beta-511 CC (OR = 0.222, P = 0.088 and OR = 0.148, P = 0.060, respectively). CONCLUSION: The results demonstrated the distribution of CRP-related polymorphisms and the interactions in Taiwanese patients with CHD.

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