TREATMENT OF EOSINOPHILIC GRANULOMA BY CORTICOTROPIN: REPORT OF 4 CASES WITH DISAPPEARANCE OF THE BONE LESIONS*

Résumé fourni par la source

IN 1952 Flosi et al. (1) reported the initial results of the use of corticotropin (ACTH) in the treatment of eosinophilic granuloma, showing recession of the tumoral mass as well as partial disappearance of the bone lesions. The choice of corticotropin, which stimulates the secretion of the glucocorticoid hormones, was based on the known action of the latter upon circulating eosinophils (2). Lackey et al. (3) and Mazzitello (4) observed beneficial effects from corticotropin therapy in cases in which eosinophilic granuloma was localized in the lung, and there have been a few other favorable reports (5, 6). The object of this paper is to record the course of a case (observed for forty-three months) in which there was remission of the bone lesions, and to describe 3 later cases which confirmed the initial results. CASE REPORT R.P.S. (H.C. 271887), a 5-year-old girl, was admitted on February 28, 1952. About nine months prior to admission her father had noticed a swelling in the right occipital region which se...

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.