A novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical study
Rattachement africain : hk, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The injection of bone cement by minimally invasive techniques for the treatment of vertebral body fractures or for stabilization of an osteoporotic vertebral body is regarded as promising in spinal surgery. The purpose of this study was to develop a novel injectable bioactive bone cement to address such concerns. The cement was composed mainly of strontium-containing hydroxyapatite (Sr-HA) filler and Bisphenol A Diglycidylether Dimethacrylate (D-GMA) resin. The Sr-HA filler was prepared by precipitation and calcination, then analyzed with Fourier transform infrared (FTIR) spectra and X-ray diffraction (XRD) patterns. Samples of strontium-containing hydroxyapatite cement (SrHAC) were formed by a combination of powder filler and resin matrix, with the setting time and peak temperature recorded. Cell relative growth rate (RGR), Tetrazolium bromide (MTT), and haemolysis tests were used to detect initial in vitro biocompatibility of the new cement. In vitro spinal biomechanical testing and morphological observation after bone cement injection were performed on pig spines. Results indicate that the setting time and peak temperature of the cement was 15 min and 55 degrees C, respectively. Cytotoxicity of the cement was class 1 (no cytotoxicity) and haemolysis was 1% (no haemolysis). Stiffness after cement injection and fatigue loading were 112% and 95% of the intact bone, respectively, which is similar to that of natural bone. Radiopacity of SrHAC allowed easy radiographic imaging. The use of SrHAC cement is, thus, promising in spinal surgery.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical study
- Date Crossref
- 01/01/2000
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese University of Hong Kong pays non établi dans la noticeUniversité ou école supérieure
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Columbia University Irving Medical Center pays non établi dans la noticeÉtablissement de santé
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University Medical Center Y. W. Li pays non établi dans la noticeÉtablissement de santé
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New York University pays non établi dans la noticeUniversité ou école supérieure
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University of Hong Kong Department of Orthopaedic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Second Medical University Shanghai Biomaterial Research & Test Centre pays non établi dans la noticeUniversité ou école supérieure
Chinese University of Hong Kong, Columbia University Irving Medical Center et Y. W. Li — University Medical Center, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.