Dexamethasone cyclophosphamide pulse therapy in systemic lupus erythematosus: A case report

Résumé fourni par la source

OBJECTIVE: To put systemic lupus erythematosus (SLE) in remission for a prolonged period. METHODS: Dexamethasone cyclophosphamide pulse (DCP) therapy was used in a 40-year-old female with SLE of 3 years' duration. DCP therapy comprises an intravenous infusion of 100 mg dexamethasone in 500 ml of 5% glucose over 1-1(1/2) hours on 3 consecutive days along with cyclophosphamide 500 mg in the same drip on the first day. This was repeated at 4-week intervals till 9 months after all the lesions cleared. In between the DCP therapy she was given 50 mg cyclophosphamide orally daily. RESULTS: The skin lesions cleared with 11 DCP therapies. There was no relapse 24 months after stopping all treatment. CONCLUSION: DCP therapy appears to put SLE into prolonged remission.

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