Synthesis of 2-Methoxybenzoylhydrazone and Evaluation of their Antileishmanial Activity

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my 2-Methoxybenzoylhydrazones 1-25 were synthesized from 2-methoxybenzoylhydrazide which was obtained from methyl-2methoxybenzoate by refluxing with hydrazine hydrate for 5 h which was then crystallized from methanol. 2-Methoxybenzoylhydrazones were prepared by condensing 2-methoxybenzoylhydrazide with different aromatic aldehydes in refluxing ethanol for 3 to 4 hour in high yield. Compounds 1-25 showed varying degrees of antileishmanial activities with IC 50 values ranging between 1.95 -88 M, as compared to standard pentamidine (IC 50 = 5.09 M). Compounds 10 (IC 50 = 1.95 M), 11 (IC 50 = 2. 49 M), and 2 (IC 50 = 3.29 M) were found to be more active than standard pentamidine (IC 50 = 5.09 M). Compounds 7 (IC 50 = 7.64 M), 8 (IC 50 = 13.17M), 18 (IC 50 = 13.15 M), and 24 (IC 50 = 15.65 M) exhibited good activities. Compounds 3 (IC 50 = 28.24 M), 1 (IC 50 = 31.47 M), 12, (IC 50 = 31.56 M), 4 (IC 50 = 33.2 M), 15 (IC 50 = 34.85 0.48 M), 5 (IC 50 = 35.41 M), 9 (IC 50 = 40.07 M), and 19 (IC 50 = 45.67 M) were found to be moderately active. Compounds 13, 14, 16, 17, 20-23 and 25 showed weak activities with IC 50 values between 57.41 to 88.56 M. Only compound 6 was found to be completely inactive.

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