569 RISK OF SEEDING AND METASTASIS IN THE THORACIC OR ABDOMINAL WALL DUE TO RFA AND BIOPSY OF HCC ON CIRRHOSIS. SINGLE CENTRE EXPERIENCE. CAUTIONARY NOTE

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Results: Univariate analysis by means of the Cox Proportional Hazard Regressions revealed that 15 factors were prognostic predictor including gamma glutamyl transferase, Alkaline phosphatase, preoperative total bilirubin level, liver cirrhosis, Child-Pugh classification, postoperative ascites, time of operation, preoperative total bilirubin level, tumor rupture, TNM staging, Edmonson grade tumor size, HLA-DR alpha, b-catenin and DNA methyltransferase 1 P < 0.05.In a multivariable Cox regression model analysis found that the independent significant parameters were TNM staging(RR: 1.849, 95%:1.293-2.645)preoperative total bilirubin level (RR: 2.539, 95%:1.430-4.509),intraoperative blood loss(RR: 1.987, 95%:1.083-3.643),HLA-DR alpha (RR: 0.350, 95%:0.198-0.616)and DNA methyltransferase 1 (RR: 2.570, 95%:1.401-4.715).These variables can be used to calculate a risk score (R) for HCC patients after resection and were developed a HCC prognostic estimation formula (HPEF).ROC curve revealed that the accuracy of HPEF is the best among the five prognostic estimation systems.Conclusions: The results confirmed that it is feasible to develop an estimation system to predict prognosis in HCC patients after resection, based on independent prognostic biomarkers and clinical factors.Our system provide a more precise prognosis than traditional system for individuals who undergoing hepatic resection.

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