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DIALYSIS. EPIDEMIOLOGY, OUTCOME RESEARCH, HEALTH SERVICES 1

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66Institutions déclarées
23Pays d’affiliation déclarés

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Le résumé fourni par la source

Introduction and Aims: Although some guidelines recommend salt restriction, few studies have examined the association between salt restriction and clinical outcomes in hemodialysis (HD) patients.Methods: We conducted a retrospective cohort study of 88,115 adult patients enrolled in the Japanese Society for Dialysis Therapy (JSDT) registry (2008) who had received HD for at least two years and were considered anuric.The primary outcome measure was all-cause mortality at one year, and the secondary outcome was cardiovascular (CV) mortality.Estimated salt intake was the main predictor, and was calculated from interdialytic weight gain and pre-and postdialysis serum sodium levels according to the validated method of Kimura and Ramdeen.Nonlinear logistic regression was used to determine the association of salt intake with mortality, adjusting for age, gender, body mass index, vintage of HD, dialysis time, Kt/V, protein catabolic rate normalized to body weight, comorbid conditions, type of vascular access, serum potassium, phosphate, calcium, CRP level, and endotoxin level in dialysate.Cubic splines were plotted and the reference was median salt intake.Salt consumption was categorized by intake levels of 2 g per day and the association with mortality examined.Results: Median [25th-75th percentile] salt intake at baseline was 6.4 [4.6-8.3]g per day.At one year, all-cause mortality occurred in 1,845 (2.1%) patients, including cardiovascular mortality in 821 (0.9%).We observed an association between low salt intake and clinical outcomes (all-cause and CV mortality) (Fig. 1).We observed the highest all-cause mortality in the low salt group (<6g/day) (Fig. 2), and no association between all-cause mortality and high salt intake.Further, we observed similar associations between salt intake and CV mortality.Conclusions: Low salt intake is associated with all-cause and CV mortality.These findings do not support current clinical guidelines, which recommend restricting salt intake to less than 6g per day.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
DIALYSIS. EPIDEMIOLOGY, OUTCOME RESEARCH, HEALTH SERVICES 1
Date Crossref
01/05/2014
Éditeur
Oxford University Press (OUP)
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

Kurume UniversityKyoto UniversityUniversity of DubrovnikHelsinki University HospitalUniversity of OxfordJapanese Society for Dialysis TherapyFresenius Medical Care (United States)NefrovisieSHOWA Medical University Fujigaoka HospitalVA Greater Los Angeles Healthcare SystemFresenius Medical Care North America (United States)Opća bolnica DubrovnikRutgers, The State University of New JerseyPontifícia Universidade Católica do ParanáFresenius Medical Care (Germany)Imperial College LondonWonkwang UniversityEwha Womans UniversityUniversity of MichiganAnn Arbor Center for Independent LivingVanderbilt UniversitySHOWA Medical University HospitalUniversity Health NetworkCroatian Meteorological and Hydrological ServiceManchester Royal InfirmaryUniversity of ManchesterHeartlands HospitalSt George HospitalUniversity of California, IrvineBrigham and Women's HospitalThe University of SydneyCliniques Universitaires Saint-LucMemphis VA Medical CenterDianetRenal Research InstituteŠibenik University of Applied SciencesLeiden UniversityAlexion Pharma (Switzerland)Baxter (United States)Menzies School of Health ResearchCharité - Universitätsmedizin BerlinThe George Institute for Global HealthSt George's HospitalThe George Institute for Global HealthUniversity of SplitFatima Jinnah Dental CollegeRuđer Bošković InstituteEkonomski InštitutUniversity of HelsinkiQueen's UniversityPeking UniversityToho UniversityCarol Davila University of Medicine and PharmacyOslo University HospitalUniversity of OsloCharles UniversityUniversity of MiyazakiNational University of SingaporeMemorial Hospital of South BendCapital Medical UniversityHeidelberg UniversityOita UniversityDaegu Catholic UniversityPomeranian Medical UniversityTallinn University of TechnologyLinköping University

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Medical Case Reports and StudiesClinical Laboratory Practices and Quality ControlImmunotoxicology and immune responses

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