Influence of Antibacterial Prophylaxis on Burn Infection

Le résumé fourni par la source

Staphylococcus aureus was the most common organism colonizing the burn wound and causing burn wound infection. Pseudomonas aeruginosa caused wound infection almost as often and was the organism most frequently isolated from blood cultures. A delay of more than 24 hours between burn and initiation of definitive wound care increased the incidence of burn wound infection due to S. aureus and group A streptococci. In patients admitted within 24 hours of burn, the incidence of burn wound infection due to group A streptococci did not differ significantly between those who did or did not receive a prophylactic systemic antibiotic Silver sulfadiazine cream was a more effective topical prophylactic antibacterial against P. aeruginosa but less effective than gentamicin used topically against S. aureus and enterococcus. As indicated by seven years of use, topical silver sulfadiazine remains effective prophylaxis against infection due to P. aeruginosa and other gram-negative organisms, although infection due to enterococcus has increased

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