Analysis of Structure-Function Relationships of p94 by Proteinase-Trapping System

Le résumé fourni par la source

-independence during exhaustive autolysis and concomitant proteolysis of non-self substrates. Mutations in the p94 gene impairing p94 protease activity causes muscular dystrophy called calpainopathy, indicating that p94 functions as an indispensable proteolytic modulator for skeletal muscle. Studies have implicated multiple factors in regulation of p94 activity; interaction with connectin/titin, a gigantic sarcomeric protein (1-3), developmental stage of myofibrils (4), and specific insertion sequences in p94 itself (5). The aim of this study is to comprehensively profile the structural basis of p94 enabling activation in the cytosol without an extra Ca

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