PO-0155 Evaluation Of Growth Hormone Deficiency (ghd) In Children With Acute Lymphoblastic Leukemia (all) And Non-hodgkin’s Lymphoma (nhl)

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Introduction Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and non-Hodgkin’s lymphoma (NHL) is the most common childhood cancer.these children may suffer from some late effects of treatments such as endocrinopathies like thyroid, pituitary, metabolism disfunctions. Growth Hormone Deficiency (GHD) is one of the causes of short stature. Material and methods During a 3 years cross-sectional research in Dr Sheikh children hospital in Mashhad, we studied on 50 children with ALL (n = 25), NHL (n = 25) who received chemotherapy alone (n = 25) or plus radiation (n = 25). Patients with height less than 5th percentile, were evaluated for GHD via insulin stimulating test. Also for short stature workup in all patients thyroid function test were done. Results We found 6 (12%) children with height less than 5th percentile who 5(83.33% of them or 10% of total) had GHD. There was no statistical correlation between type of disease also type of treatment and GHD (respectively p-value = 0. 667, 0.189) due to small sample size. Among these 6 patients, 5 children (83.33% of them) undergone radiation and 4 patients (66.66% of them) had ALL. There was 2(4% total) cases of subclinical hypothyroidism but with normal height. According to BMI (body mass index) access 2(4% total) patients had overweight. Conclusion In our study ALL patients who received radiation had unfavourable state for height and endocrine side effects. So it seems more attention to radiotherapy complications in children with cancer especially ALLs is needed to improve their quality of life.

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