Clinical Characteristics of Acanthamoeba Keratitis Infections in 28 States, 2008 to 2011
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Le résumé fourni par la source
PURPOSE: The aim was to describe a geographically and clinically diverse sample of cases of Acanthamoeba keratitis (AK) and establish the risk factors for poor outcomes among patients with this disease. METHODS: We conducted a retrospective, population-based case series of 116 patients with AK identified through a national surveillance network. Data were collected via a medical record review by diagnosing ophthalmologists and by phone interviews with patients. Exact logistic regression modeling was used to determine risk factors for poor visual outcomes. RESULTS: Among patients with data available on contact lens use, it was found that 93.3% wore contact lenses. The median time from symptom onset to care seeking was 2 days, whereas the median time from symptom onset to diagnosis was 27 days. Keratoplasty was performed in 27 of 81 patients with available outcome data and was more likely in patients >40 years old [odds ratio (OR) 5.25, 95% confidence interval (CI) 1.49-21.92]. When adjusted for age, the risk factors for keratoplasty included the presence of a ring infiltrate (OR 40.00, 95% CI 3.58-447.0) or any sign of stromal invasion (OR 10.48, 95% CI 2.56-55.09). One-third of patients with available data on best-corrected visual acuity had a best-corrected visual acuity <20/200, with the presence of a ring infiltrate as the only significant predictor of this outcome when adjusted for age (aOR 3.45, 95% CI 1.01-12.31). CONCLUSIONS: AK remains challenging to diagnose. Consequently, patients with advanced disease are more likely to have poor outcomes, particularly if they are older. The increasing awareness of AK among general eye care providers may shorten referral times and potentially improve outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Characteristics of Acanthamoeba Keratitis Infections in 28 States, 2008 to 2011
- Date Crossref
- 01/02/2014
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Oregon Health & Science University pays non établi dans la noticeUniversité ou école supérieure
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New York Eye and Ear Infirmary pays non établi dans la noticeÉtablissement de santé
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Case Western Reserve University pays non établi dans la noticeUniversité ou école supérieure
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Oregon State Hospital pays non établi dans la noticeÉtablissement de santé
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Northwell Health pays non établi dans la noticeÉtablissement de santé
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Florida Department of Health pays non établi dans la noticeOrganisme public
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Oregon Health and Science University †Casey Eye Institute pays non établi dans la noticeUniversité ou école supérieure
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Centers for Disease Control & Prevention pays non établi dans la noticeInstitution
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State of Oregon pays non établi dans la noticeInstitution
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North Shore Long Island Jewish Health System pays non établi dans la noticeOrganisation à but non lucratif
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Florida Dept. of Health pays non établi dans la noticeInstitution
Oregon Health & Science University, New York Eye and Ear Infirmary et Case Western Reserve University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.