Clinical Investigations Dosimetric Improvements in Balloon Based Brachytherapy Using the Contura Multi-Lumen Balloon (MLB) Catheter to Deliver Accelerated Partial Breast Irradiation

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Purpose: Preliminary dosimetric findings in patients managed with the Contura ® Multi-Lumen Balloon (MLB) breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI) on a multi-institutional phase IV registry trial were reviewed.Material and methods: CT-based 3D planning with dose optimization was performed for all patients.For the study, new ideal dosimetric goals were developed: 1) ≥ 95% of the prescribed dose (PD) covering ≥ 90% of the target volume (TV), 2) a maximum skin dose ≤ 125% of the PD, 3) maximum rib dose ≤ 145% of the PD, and 4) the V150 ≤ 50 cc and V200 ≤ 10 cc.The frequency of concurrently achieving these dosimetric goals using the Contura ® MLB was investigated.Results: 194 cases were evaluable.Employing the MLB, all ideal dosimetric criteria were achieved in 76% of cases.Evaluating dosimetric criteria separately, 90% and 89% of cases met the new ideal skin and rib dose criteria, respectively.In 96%, ideal TV coverage goals were achieved and in 96%, dose homogeneity criteria (V150 and V200) were met.For skin spacing ≥ 5-7 mm, the median skin dose was 121% of the PD and when < 5 mm, the median skin dose was 124.4%.For rib distancees < 5 mm, the median rib dose was reduced to 136.4% of the PD.For skin spacing < 7 mm and distance to rib < 5 mm, the median skin and rib doses were concurrently limited to 121% and 142.8% of the PD, respectively. Conclusions:The Contura ® MLB catheter provides potential improvements in dosimetric capabilities (i.e., reduced skin and rib doses and improved TV coverage) in many clinical scenarios.

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