MP40-08 ROLE OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCAIN IN THE DETECTION OF KIDNEY INJURY FOLLOWING CLAMPLESS AND CLAMPED LAPAROSCOPIC PARTIAL NEPHRECTOMY

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You have accessJournal of UrologyKidney Cancer; Evaluation/Staging IV1 Apr 2014MP40-08 ROLE OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCAIN IN THE DETECTION OF KIDNEY INJURY FOLLOWING CLAMPLESS AND CLAMPED LAPAROSCOPIC PARTIAL NEPHRECTOMY Francesco Porpiglia, Daniele Amparore, Riccardo Bertolo, Emiliano Aroasio, Francesca Ragni, and Cristian Fiori Francesco PorpigliaFrancesco Porpiglia More articles by this author , Daniele AmparoreDaniele Amparore More articles by this author , Riccardo BertoloRiccardo Bertolo More articles by this author , Emiliano AroasioEmiliano Aroasio More articles by this author , Francesca RagniFrancesca Ragni More articles by this author , and Cristian FioriCristian Fiori More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1343AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives NGAL (Neutrophil gelatinase-associated lipocain), a protein overexpressed in case of renal injury and dosable in both plasma and urine, is being discussing as a precocious biomarker of acute kidney injury. The aim of this study was the evaluation of role of urinary-NGAL as marker to detect and quantify renal injury in patients who underwent clampless or clamped Laparoscopic Partial Nephrectomy (LPN). Methods Seventy-five consecutive patients who underwent LPN between 3/2012 and 7/2013 were involved in this study. Patients were divided into two groups according to the surgical technique used: Group A-37pts treated with clampless-LPN (cl-LPN) and Group B-38pts treated with “clamped” (c-LPN). Demographic, perioperative and pathological data were recorded. NGAL urinary values were dosed on urine samples collected preoperatively and 24hours, 5 days, 3 months after surgery by ELISA in all patients. Serum Creatinine (SCr) and GFR were determined at the same time points. Differences between the groups and within each group at different time points were tested, pvalues<0.05 were considered significant. Results The two groups resulted comparable in terms of demographic, preoperative and pathological data. Mean SCr and GFR values were not different between group A and B and were stable at every time point. NGAL values were 29.3 ng/ml, 32.8 ng/ml, 73.6 ng/ml, 31.5 ng/ml in goup A and 26.5 ng/ml, 70.2 ng/ml, 87.8 ng/ml, 32.0 ng/ml in group B, respectively at baseline, 24 hours, 5 days and 3 months after surgery. Analyzing each group, a statistically significant increase of NGAL values was found from baseline to 24 hours in Group B (p=0.03) while, in Group A, no significant increase was found until 5 day after surgery (<0.01). For both groups no differences were found when specifically testing NGAL baseline versus 3rdmonth value (Group A; p=0.85, Group B; P=0.12). When comparing differences between the Groups A and B in terms of NGAL values, the only significant difference was observed 24 hours after surgery (p=0.04). Conclusions We observed a progressive increase of urinary NGAL values from baseline until the fifth post-operative day and a return to basal values at 3rd month. c-LPN Group, compared with cl-LPN Group, showed a steeper and higher increase of NGAL values in the early postoperative period. Conversely, SCr and GFR values remained stable in all measurements. These data suggest that NGAL could be a useful molecular marker to evaluate the trend of acute kidney damage, increasing precociously and strongly in case of renal ischemia. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e437 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Francesco Porpiglia More articles by this author Daniele Amparore More articles by this author Riccardo Bertolo More articles by this author Emiliano Aroasio More articles by this author Francesca Ragni More articles by this author Cristian Fiori More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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