Development of a Diet for Long-Term Raising of F344 Rats. Relationship between Dietary Digestible Crude Protein Content and Digestible Energy Content.
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Mice and rats are frequently subjected to long-term raising in studies of aging. These animals are usually given growing or breeding diets from a young age. This raising method causes diseases such as chronic nephropathy with proteinuria due to nutritional excess. Consequently, a long-term raising study on male F344/DuCrj rats using nine sorts of diets differing in crude protein (CP; 12, 28, 44%) and digestible energy (DE; 2.8, 3.7, 4.5 kcal/g) contents was carried out. It was found that feed consumption was regulated by DE, not digestible crude protein (DCP) intake. Body weight was controlled within low energy areas, and was not influenced by feed or DCP intake. The liver and kidney weight at 105 weeks of age increased in response to an increase in the level of CP in the diet. Chronic nephropathy was severe in rats fed high protein diets and moderate levels of protein with moderate to high energy diets. Fatty liver and bile duct hyperplasia were found in rats fed a high protein and high energy diet. Few pathological findings of kidney and liver were found in the low protein and low energy diet group. The reduction of disorders attributable to excess energy or inappropriate diet suggests that low protein and low energy diets are most suitable for long-term raising in this strain of rat.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Development of a Diet for Long-Term Raising of F344 Rats. Relationship between Dietary Digestible Crude Protein Content and Digestible Energy Content.
- Date Crossref
- 01/01/2002
- Éditeur
- Japanese Association for Laboratory Animal Science
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Okayama University pays non établi dans la noticeUniversité ou école supérieure
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Nosan Corporation (Japan) pays non établi dans la noticeEntreprise
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Tokyo Metropolitan Institute of Gerontology pays non établi dans la noticeStructure de recherche
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Faculty of Agriculture Laboratory of Animal Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Research & Development Center pays non établi dans la noticeInstitution
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Present address pays non établi dans la noticeInstitution
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Department of Laboratory Animal Science pays non établi dans la noticeStructure de recherche
Okayama University, Nosan Corporation (Japan) et Tokyo Metropolitan Institute of Gerontology, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.