P2‐380: ABSENCE OF A “WIDOWHOOD EFFECT” ON INCIDENCE OF DEMENTIA IN COGNITIVELY NORMAL RESEARCH SUBJECTS

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Spousal death is associated with negative health outcomes such as the “broken heart syndrome”. The impact of spousal death on the risk of developing dementia is unknown. We hypothesized that spousal demise would accelerate the incidence of dementia in surviving spouses with normal cognition. Subjects enrolled in an NIA-Alzheimer's Disease Center who were married and cognitively normal at entry were identified from the National Alzheimer's Coordinating Center (NACC) database for Uniform Data Set visits conducted between September 2005 and September 2013.Those who became divorced or separated during followup were excluded. The primary outcome was age of dementia diagnosis. Cox regression was used to compare the incidence of dementia among subjects who became widowed with that of subjects who remained married. 6,088 subjects were married and cognitively normal at entry.59 subjects subsequently divorced or separated and were excluded.1583 who had no follow-up were excluded. Of those remaining, 398 became widowed and 4048 remained married. Number of visits ranged from 2 to 9 (mean 4.3, SD 1.9), with study duration up to 7.8 years (m ean 3.8, SD 2.0).218 subjects became demented.The median age of dementia onset in the widowed group was not younger than in the married group (96 vs 96 y, HR 0.92, 95% CI 0.66 to 1.29, P .64).Adjustment for sex, presence of an ε4 allele, or age at first visit did not increase the HR for loss of a spouse.

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