Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties of Bone by Micro-MRI in the Distal Tibia of Men With Hypopituitarism
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Le résumé fourni par la source
CONTEXT: Severe deficiencies of testosterone (T) and GH are associated with low bone mineral density (BMD) and increased fracture risk. Replacement of T in hypogonadal men improves several bone parameters. Replacement of GH in GH-deficient men improves BMD. OBJECTIVE: Our objective was to determine whether T and GH treatment together improves the structural and mechanical parameters of bone more than T alone in men with hypopituitarism. DESIGN AND SUBJECTS: This randomized, prospective, 2-year study included 32 men with severe deficiencies of T and GH due to panhypopituitarism. INTERVENTION: Subjects were randomized to receive T alone (n = 15) or T and GH (n = 17) for 2 years. MAIN OUTCOME MEASURES: We evaluated magnetic resonance microimaging-derived structural (bone volume fraction [BVF] and trabecular thickness) and mechanical (axial stiffness [AS], a measure of bone strength) properties of the distal tibia at baseline and after 1 and 2 years of treatment. RESULTS: Treatment with T and GH did not affect BVF, thickness, or AS differently from T alone. T treatment in all subjects for 2 years increased trabecular BVF by 9.6% (P < .0001), trabecular thickness by 2.6% (P < .001), and trabecular AS by 9.8% (P < .001). In contrast, testosterone treatment in all subjects significantly increased cortical thickness by 2.4% (P < .01) but decreased cortical BVF by -4.7% (P < .01) and cortical AS by -6.9% (P < .01). CONCLUSION: Combined T and GH treatment of men with hypopituitarism for 2 years did not improve the measured structural or mechanical parameters of the distal tibia more than T alone. However, testosterone significantly increased the structural and mechanical properties of trabecular bone but decreased most of these properties of cortical bone, illustrating the potential importance of assessing trabecular and cortical bone separately in future studies of the effect of testosterone on bone.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties of Bone by Micro-MRI in the Distal Tibia of Men With Hypopituitarism
- Date Crossref
- 01/04/2014
- Éditeur
- The Endocrine Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Children's Hospital of Philadelphia and Nutrition (B.S.Z.) pays non établi dans la noticeOrganisme public
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University of California R.S.S.) pays non établi dans la noticeUniversité ou école supérieure
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The Lundquist Institute pays non établi dans la noticeOrganisation à but non lucratif
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Los Angeles Medical Center pays non établi dans la noticeÉtablissement de santé
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Translational Therapeutics (United States) pays non établi dans la noticeEntreprise
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University of Pennsylvania pays non établi dans la noticeUniversité ou école supérieure
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Division of Endocrinology pays non établi dans la noticeInstitution
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Laboratory of Structural NMR Imaging pays non établi dans la noticeStructure de recherche
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Department of Biostatistics and Epidemiology (W.G.) pays non établi dans la noticeInstitution
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Raymond and Ruth Perelman School of Medicine the Clinical and Translational Research Center (S.C.K.) pays non établi dans la noticeUniversité ou école supérieure
and Nutrition (B.S.Z.) — Children's Hospital of Philadelphia, R.S.S.) — University of California et The Lundquist Institute, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.