Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs
Rattachement africain : us, kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Distribution and characterization of interlukin-10 (IL-10)-secreting cells in lymphoid tissues of pigs naturally infected with porcine circovirus type 2 (PCV2) were evaluated in accordance with PCV2 antigen detection. After screening a total of 56 pigs showing the symptoms of postweaning multisystemic wasting syndrome (PMWS), 15 pigs were PCV2 positive and 5 pigs, which showed stronger positive signals over multiples tissues were further investigated. This study showed that in PCV2-infected lymphoid tissues, particularly mandibular lymph node, spleen and tonsil, IL-10 expression was mainly localized in T-cell rich areas but rarely in B cell rich areas. IL-10 was highly expressed in bystander cells but rarely in PCV2-infected cells. Elevated IL-10 expression was predominantly associated with T cells, but rarely with B cells or with macrophages. The results of this study provide evidence for the role of IL-10 in chronic PCV2 infection and its relation to PCV2 antigen in affected tissues. Constantly elevated levels of IL-10 lead to immunosuppression in persistent and chronic viral infections. The increased IL-10 expression observed in PCV2 infection in this study suggests that IL-10-mediated immunosuppression may play an important role in the pathogenesis and maintenance of naturally occurring PCV2 infection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs
- Date Crossref
- 01/01/2010
- Éditeur
- The Korean Society of Veterinary Science
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Nebraska–Lincoln pays non établi dans la noticeUniversité ou école supérieure
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Konkuk University pays non établi dans la noticeUniversité ou école supérieure
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School of Veterinary Medicine and Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Veterinary and Biomedical Sciences and Nebraska Center for Virology pays non établi dans la noticeUniversité ou école supérieure
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College of Veterinary Medicine Department of Veterinary Pathology pays non établi dans la noticeUniversité ou école supérieure
University of Nebraska–Lincoln, Konkuk University et School of Veterinary Medicine and Biomedical Sciences, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.