The protective effects of human urinary kallidinogenase (SK-827) on myocardial ischemia/reperfusion injury in rabbits

Résumé fourni par la source

SK-827 plays a role in vasodilatation and improving microcirculation by way of facilitating kininogen to release kinin in vivo .The protective effects of SK-827 on myocardial ischemia/reperfusion(b’R) injury were investigated in the isolated rabbit hearts. Coronary effluent Mb and LDH content, myocardial MDA and ATP level were assayed by biochemical technique. The results showed that in SK-827 group, coronary flow increased, cellular Mb and LDH leakage decreased, myocardial MDA content decreased and ATP content increased as compared with LR group. These findings indicated that SK-827 potently protected myocardium from L’R injury, suggesting that SK-827 might have an implication in the treatment of clinical myocardial I/R injury.

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