Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism
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Le résumé fourni par la source
Staphylococcal pathogenicity islands (SaPIs) carry superantigen and resistance genes and are extremely widespread in Staphylococcus aureus and in other Gram-positive bacteria. SaPIs represent a major source of intrageneric horizontal gene transfer and a stealth conduit for intergeneric gene transfer; they are phage satellites that exploit the life cycle of their temperate helper phages with elegant precision to enable their rapid replication and promiscuous spread. SaPIs also interfere with helper phage reproduction, blocking plaque formation, sharply reducing burst size and enhancing the survival of host cells following phage infection. Here, we show that SaPIs use several different strategies for phage interference, presumably the result of convergent evolution. One strategy, not described previously in the bacteriophage microcosm, involves a SaPI-encoded protein that directly and specifically interferes with phage DNA packaging by blocking the phage terminase small subunit. Another strategy involves interference with phage reproduction by diversion of the vast majority of virion proteins to the formation of SaPI-specific small infectious particles. Several SaPIs use both of these strategies, and at least one uses neither but possesses a third. Our studies illuminate a key feature of the evolutionary strategy of these mobile genetic elements, in addition to their carriage of important genes-interference with helper phage reproduction, which could ensure their transferability and long-term persistence.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism
- Date Crossref
- 18/09/2012
- Éditeur
- National Academy of Sciences
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University Medical Center Skirball Institute Program in Molecular Pathogenesis and Departments of Microbiology and Medicine pays non établi dans la noticeÉtablissement de santé
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New York University pays non établi dans la noticeUniversité ou école supérieure
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Virginia Commonwealth University Department of Microbiology and Immunology pays non établi dans la noticeUniversité ou école supérieure
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Consejo Superior de Investigaciones Científicas pays non établi dans la noticeOrganisme public
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Instituto de Biomedicina de Valencia Department of Genomics and Proteomics pays non établi dans la noticeStructure de recherche
Skirball Institute Program in Molecular Pathogenesis and Departments of Microbiology and Medicine — University Medical Center, New York University et Department of Microbiology and Immunology — Virginia Commonwealth University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.