THE REDOX STATUS OF EXPERIMENTAL HEMORRHAGIC SHOCK AS MEASURED BY CYCLIC VOLTAMMETRY
Rattachement africain : nz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Hemorrhagic shock (HS) leads to reactive oxygen species production. However, clinicians do not have access to bedside measurements of the redox status during HS. Cyclic voltammetry (CyV) is a simple electrochemical method of measuring redox status. The aims of this study were to 1) report the first application of cyclic voltammetry to measure the acute changes in serum redox status after HS, 2) to contrast it with another severe systemic disease with a different redox pathology (acute pancreatitis [AP]), and 3) to describe the response of CyV over time in a resolving model of AP. In the acute study, 24 male Wistar rats were randomized into three groups: groups 1 (control), 2 (AP), and 3 (HS). In the time-course study, 28 rats were randomized to a sham-control as well as 6 and 24 h post-AP cohorts, respectively.Cyclic voltammetry was performed using a three-electrode system. In the acute study, the first and second voltammetric peaks increased significantly in HS. In contrast, within the AP group, only the first voltammetric peak showed a significant increase. The first voltammetric peak correlated with plasma protein carbonyls (PCs) and with thiobarbituric acid-reactive substances, whereas the second voltammetric peak correlated positively with plasma protein carbonyls. In the second study, the first voltammetric peak correlated with physiological improvements. Here, we showed that serum CyV could respond to the serum redox change in HS and AP. Cyclic voltammetry warrants evaluation as a potential real-time beside measure of a patient's redox status during shock.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- THE REDOX STATUS OF EXPERIMENTAL HEMORRHAGIC SHOCK AS MEASURED BY CYCLIC VOLTAMMETRY
- Date Crossref
- 01/05/2010
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Auckland Maurice Wilkins Centre for Molecular Biodiscovery pays non établi dans la noticeUniversité ou école supérieure
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University of Otago pays non établi dans la noticeUniversité ou école supérieure
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Maurice Wilkins Centre Maurice (pays nommé en fin d’affiliation)Structure de recherche
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Faculty of Medicine and Health Sciences Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Wellington School of Medicine Department of Pathology and Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Chemistry pays non établi dans la noticeInstitution
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§School of Biological Sciences Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
Maurice Wilkins Centre for Molecular Biodiscovery — University of Auckland, University of Otago et Maurice Wilkins Centre (Maurice), avec 4 autres affiliations. Pays d’affiliation : Maurice.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.