False-Negative Pregnancy Test in Hydatidiform Mole
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
A 16-year-old girl (gravida 0, para 0) presented to the emergency department with a 2-week history of nausea, vomiting, vaginal spotting, and lower leg edema. On examination we found a palpable lower abdominal mass. The patient acknowledged recent sexual activity but denied having any sexually transmitted diseases. Molar pregnancy was suspected because of the typical “snowstorm” appearance observed with ultrasound examination. The quantitative serum β-subunit of human chorionic gonadotropin (β-hCG) concentration was 746.20 IU/L (reference interval, <0.5 to 2.90 IU/L; reportable interval, 0.5–1000 IU/L). The result of a qualitative urine hCG test, however, was negative. Human error was initially suspected as the cause of the negative result in the first qualitative urine hCG test. Two experienced and well-trained senior medical technologists repeated the urine hCG test twice, but the results were still negative. The patient’s nurse also indicated that she did not think there had been mislabeling of the urine sample. Because of this discrepancy, we had a discussion with the clinicians and concluded that a hook effect might be responsible for the negative urinary hCG result and for the relatively low serum β-hCG concentration. We therefore repeated the tests at a 1 to 10 000 dilution and obtained values for serum β-hCG and urinary hCG of 3 835 000 IU/L and 4 873 400 IU/L, respectively.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- False-Negative Pregnancy Test in Hydatidiform Mole
- Date Crossref
- 01/08/2006
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kaohsiung Medical University pays non établi dans la noticeUniversité ou école supérieure
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Kaohsiung Medical University Chung-Ho Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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University Hospital Department of Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Biomedical Laboratory Science Department of pays non établi dans la noticeUniversité ou école supérieure
Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital et Department of Laboratory Medicine — University Hospital, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.