Vasopression and suspected anaphylactic reactions associated with anaesthesia

Le résumé fourni par la source

The recently produced guideline ‘Suspected Anaphylactic Reactions Associated with Anaesthesia’ [1], presents a comprehensive update on the recent knowledge of anaphylaxis and anaesthesia. We agree with the recommendations concerning the immediate management. We are however astonished that vasopressin was not even mentioned as a second line drug as it is the only substance, besides adrenaline, whose effectiveness in anaphylactic shock is supported by in vitro and in vivo data [2–5]. In profound vasodilatory shock maintaining perfusion of both brain and heart is crucial. Under these circumstances, time is often against the patient. We are convinced that early administration of low doses of vasopressin to patients refractory to standard treatment is mandatory [5]. In contrast to adrenaline, vasopressin augments systemic vascular resistance reliably [5]. We strongly recommend the integration of vasopressin as secondary management into the next guidelines.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.