THE GLYCOGENIC ACTIVITY OF CERTAIN CRYSTALLINE STEROIDS OF THE ADRENAL CORTEX WHEN ADMINISTERED SINGLY AND WITH CORTICAL EXTRACT TO FASTED, NORMAL AND ADRENALECTOMIZED RATS1

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THE MODIFIED Kendall assay procedure for the evaluation of the glycogenic factors of the adrenal cortex described in the preceding paper (Olson, et al., 1944) has been applied in glycogenic studies of the pure crystalline hormones of the cortex. Reinecke and Kendall (1943) have reported desoxycorticosterone acetate to betotally inactive in glycogenic potency and compounds A, B, and E, i.e.,dehydrocorticosterone, corticosterone, and ll-dehydro-17-hydroxycorticosterone to show “less than one-fold difference” in activity. Our results confirm these findings and extend them. By application of our modified procedure to the assay of 11-dehydrocorticosterone, corticosterone, 1 l-dehydro-17-hydroxycorticosterone, 17-hydroxycorticosterone, allopregnanepentol-3,11,17,20,21, and desoxycorticosterone acetate, certain important differences in both the slope of the regression lines obtained for these steroidsand their potency in glycogenic units have been revealed. It has been noted, further, that the administration of mixtures of the C11-oxygen-containing steroids to our assay rats under these same conditions has resulted in measurable augmentations of potency.

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