Oxidant/Antioxidant Balance in Carnitine Supplemented Rats Exposed to Chronic Hypothermic Stress

Résumé fourni par la source

Chronic stress is a major factor that contributes to several disorders. A common animal model,performed in order to evaluate the environmental experimentally-induced-stress is hypothermia. LCarnitineis a natural substance required in the energetic metabolism of the mammals, which also has anantioxidant function. The aim of the present study was to evaluate the effect of chronic hypothermic stresson oxidant/antioxidant balance in the serum and tissues, (liver and muscle), on rats with and withoutcarnitine supplementation. Rats were divided randomly into four groups of ten rats each: control group (I);hypothermic stress (II) - exposed to cold stress; supplemented with carnitine (III) supplemented withcarnitine and exposed to hypothermic stress (IV). Our experimental results showed that chronichypothermic stress increases the oxidative stress (OS) indicators in serum and tissues and decreased thoseof antioxidant (AO) defense. Carnitine supplementation in chronic hypothermic stress conditions hadbenefic effects on OS and AO defense indicators, this compound being likely to have favorable effects inan experimental hypothermic stress model.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.