Effects of protracted administration of FNT on immune function of surgical cancer patients

Résumé fourni par la source

The cumulative dose of fentanyl was 2.58 ± 1.03 mg. MNCs presented a statistically significant ( P < 0.05) increase in their phagocytic function at 48 hours while their respiratory burst activity increased significantly at 24 hours and returned to baseline values at 48 hours. Phagocytic function of PMNCs was significantly ( P < 0.05) depressed at 24 hours but recovered at 48 hours while their respiratory burst activity remained unchanged. The percentage of NK cells decreased significantly ( P < 0.05) at 48 hours. Overall, T lymphocytes as well as the subsets of T-helper and T-cytotoxic cells decreased significantly ( P < 0.05) at 24 hours but returned to baseline values at 48 hours. There was no effect on B lymphocytes. Protracted administration of recommended doses of fentanyl affects both innative and adapted immune function in surgical cancer patients. It exerts a suppressive effect on PMNCs, NKc and T lymphocytes while it is enhancing in MNCs. This effect is generally transient, reversing 36 hours after the interruption of the administration with the exception of NKc and the phagocytic function of MNCs, the changes of which are significantly persistent The different response between MNCs and PMNCs might be attributed to different opioid receptors.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.