Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists

Résumé fourni par la source

This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors. A compendium of structure—activity data is then provided that ultimately permits a description of the structural requirements for the ligand-binding site of an alpha-2 adrenergic receptor. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.