Dietary Fat Intake, Liver Function and Disease Progression in HIV+ Adults in Botswana, Africa

Résumé fourni par la source

Objective Although increased energy intake is associated with benefits in HIV+ patients, the effect of fat intake on HIV progression and liver function needs to be established. Methods After consenting 714 HIV+ asymptomatic adults, blood was drawn for chemistries, CD4 cell count and viral load. 24‐Hour Recalls were collected and analyzed by Nutribase 7.0. Results Medium CD4 cell count was 424 cells/µL, mean age was 33±8.1 (78.8% < 40 years), and 72.5% were female. Mean dietary fat intake was 38.25±31.2 g; 36% of participants had BMI>25 kg/m 2 . Total fat intake was positively associated with alkaline phosphatase (β=0.002, p=0.0025) and gamma‐glutamyl transferase levels (β=0.111, p=0.005). Total fat intake (%) was significantly associated with total cholesterol (β=0.007, p=0.027) and LDL levels (β=0.006, p=0.04). Those in the first CD4 quartile (≤399 cells/µL) had higher mean LDL (2.5±0.8 vs. 2.3±0.8 mmol/L, p=0.0273) than the rest. Compared to those in the CD4 third quartile (≥550 cells/µL), those in the first and second quartile had higher alkaline phosphatase (76.44±21.3 vs. 68.2±20.9 U/liter, p=0.015). These relationships remained significant after adjusting for BMI. Conclusion These findings support a significant association between increased dietary fat intake, adverse lipid profile, increased liver enzymes and HIV progression that is not affected by body composition. Funded by NIDA

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.