Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Recent data show that regulatory cells with transforming growth factor (TGF)-β1-dependent activity are able to restore self-tolerance in overtly diabetic non-obese diabetic (NOD) mice. Thus, TGF-β1 seems to have a relevant role in protection from autoimmune diabetes. Our aim was to investigate the possible significance of serum TGF-β1 measurement in the natural history of diabetes in NOD mice, as well as in children positive for at least one islet-related antibody. Serum TGF-β1 (both total and active) was measured by enzyme-linked immunosorbent assay at monthly intervals in 26 NOD mice during the spontaneous development of diabetes and, on a yearly basis, in nine siblings of patients with type 1 diabetes (T1D) with a follow-up of 4 years. Diabetes appeared between the 12th week of age and the end of the study period (36 weeks) in 17 mice. TGF-β1 serum level variations occurred in the prediabetic period in both NOD mice and humans and diabetes diagnosis followed a continuing reduction of active TGF-β1 (aTGF-β1) serum levels. In mice, aTGF-β1 serum levels measured at 4 weeks of age correlated positively with severity of insulitis, and negatively with percentage of insulin-positive cells. Our findings suggest that in NOD mice serum TGF-β1 levels during the natural history of the diabetes reflect the course of islet inflammation. The measurement of aTGF-β1 in islet-related antibody-positive subjects may provide insights into the natural history of prediabetic phase of T1D.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans
- Date Crossref
- 01/09/2010
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituto Superiore di Sanità pays non établi dans la noticeOrganisme public
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University of Genoa Pediatric Clinic pays non établi dans la noticeUniversité ou école supérieure
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Bambino Gesù Children's Hospital pays non établi dans la noticeÉtablissement de santé
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University of Siena Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera G. Brotzu pays non établi dans la noticeÉtablissement de santé
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University of Cagliari Department of Medical Sciences ‘Mario Aresu’ pays non établi dans la noticeUniversité ou école supérieure
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Department of Cell Biology and Neuroscience pays non établi dans la noticeInstitution
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Department of Infectious pays non établi dans la noticeInstitution
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Scientific Institute Ospedale Pediatrico Bambino Gesù pays non établi dans la noticeStructure de recherche
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National Centre for Epidemiology pays non établi dans la noticeInstitution
Istituto Superiore di Sanità, Pediatric Clinic — University of Genoa et Bambino Gesù Children's Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.